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 Brand name: rosiglitazone
Generic name: avandia, Rosiglitazone
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Significantly more female patients who received rosiglitazone experienced fractures of the upper arm, hand, or foot, than did female patients who received either metformin or glyburide. Dose related weight gain has been reported in patients treated with rosiglitazone alone and in combination with other hypoglycemic agents. Patients with ongoing edema are more likely to have adverse events associated with edema if started on combination therapy with insulin and rosiglitazone. Lower pre-treatment hemoglobin/hematocrit levels in patients enrolled in the metformin and rosiglitazone combination therapy clinical trials may have contributed to the higher reporting rate of anemia in these studies [see Adverse Reactions (6. However, in 26-week double-blind, fixed-dose studies of rosiglitazone added to insulin, edema was reported with higher frequency (rosiglitazone in combination with insulin, 14. 3%, respectively) were observed for rosiglitazone maleate alone and in combination with other hypoglycemic agents.

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